Related Publications

New functions of aminoacyl-tRNA synthetases beyond translation.

Guo M, Yang XL, Schimmel P.

Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74.

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.

Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL.

Nat Struct Mol Biol. 2010 Jan;17(1):57-61.

Functional expansion of human tRNA synthetases achieved by structural inventions.

Guo M, Schimmel P, Yang XL.

FEBS Lett. 2010 Jan 21;584(2):434-42.

The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.

Ghanipour A, Jirström K, Pontén F, Glimelius B, Påhlman L, Birgisson H.

Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2949-56

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.

Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang XL, Schimmel P, Norga K, Timmerman V, Callaerts P, Jordanova A.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11782-7

A tipping point for mistranslation and disease.

Schimmel P, Guo M.

Nat Struct Mol Biol. 2009 Apr;16(4):348-9. 

Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability.

Cheng G, Zhang H, Yang X, Tzima E, Ewalt KL, Schimmel P, Faber JE.

Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1138-46. 

Aminoacyl tRNA synthetases and their connections to disease.

Park SG, Schimmel P, Kim S.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11043-9.

An editing activity that prevents mistranslation and connection to disease.

Schimmel P.

J Biol Chem. 2008 Oct 24;283(43):28777-82. 

Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.

Zhou Q, Kiosses WB, Liu J, Schimmel P.

Methods. 2008 Feb;44(2):190-5.

Gain-of-function mutational activation of human tRNA synthetase procytokine.

Yang XL, Kapoor M, Otero FJ, Slike BM, Tsuruta H, Frausto R, Bates A, Ewalt KL, Cheresh DA, Schimmel P.

Chem Biol. 2007 Dec;14(12):1323-33.

Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.

Nangle LA, Zhang W, Xie W, Yang XL, Schimmel P.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11239-44.

 

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.

Xie W, Nangle LA, Zhang W, Schimmel P, Yang XL.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9976-81.