About Us: 

aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. 

Overview:

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. 

Role Description: 

We are seeking a highly motivated and experienced individual to lead and optimize our end-to-end external supply chain from Drug Product to 3PL readiness. This role is critical in ensuring the seamless flow of our drug development process, from early clinical stages through successful commercial launch. If you thrive in a dynamic environment and possess a unique blend of project management expertise, technical understanding, and logistical acumen, then this opportunity is for you.

Primary Responsibilities:

• • Develop and manage comprehensive project plans for all supply chain & serialization activities, ensuring alignment with clinical and commercial objectives.
  • Define project scope, timelines, and resource allocation, proactively identifying and mitigating potential roadblocks.
  • Collaborate closely with CMC, Quality, Clinical, and Commercial teams, acting as a subject matter expert on external manufacturing capabilities and potential supply chain risks. 
  • Contribute to supply chain budgeting and timeline development, ensuring seamless information flow across all stages of drug development.
  • Oversee all aspects of packaging, labeling, and distribution activities, coordinating shipments to clinical sites, 3PLs and regional depots. 
  • Manage relationships with third-party suppliers and vendors, ensuring timely delivery of materials and components.
  • Lead monthly demand and supply planning meetings, driving the implementation of a robust Integrated Business Planning / Sales and Operations Planning process. 

• Analyze supply chain data to identify opportunities for process optimization and cost savings.

• Author clear and concise standard operating procedures (SOPs) and work instructions. 

• Ensure compliance with all relevant regulations (CGMP, GCP) throughout our supply chain operations.

• Occasional travel will be required

 

Qualifications:

• • Bachelor’s degree in engineering, Supply Chain, Business, or a related field.
  • 8+ years of relevant experience in a biotechnology or pharmaceutical company in a supply chain management capacity.
  • Demonstrated project management skills with a proven track record of successful project delivery in a dynamic environment.
  • Expertise in dealing with CPOs and serialization partners.
  • Expertise in supply chain best practices, inventory management, and demand forecasting.
  • Proficient in MS Excel, Smartsheet, Visio, ERP systems, and Power BI (or similar applications).
  • Excellent analytical, problem-solving, and communication skills.
  • Understanding of pharmaceutical development and manufacturing processes is desirable.

• APICS or CSCMP certification is a plus.

Further Recruiting Information

The salary range for this position is $150,000-$180,000 per year. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability, time-off, and 401(k)-matching contribution.

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.  aTyr Pharma, Inc. is committed to providing equal employment opportunities to all applicants and employees. We are committed to providing a workplace free of discrimination and harassment based on any protected characteristic. In accordance with the Americans with Disabilities Act (ADA) and other applicable laws, we will provide reasonable accommodations for qualified individuals with disabilities who are employees or applicants for employment, unless to do so would cause an undue hardship.

For consideration, please submit your resume and cover letter referencing job #223JA to jobs@atyrpharma.com.  aTyr Pharma, Inc. is an EEO employer.

About Us: 

aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. 

Overview:

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. 

Role Description: 

We are seeking a highly motivated and experienced individual to be an external manufacturing leader to ensure right first time delivery for efzofitimod late-phase drug substance. This role is critical for ensuring timely process validation execution and enabling a successful on time launch with high quality drug substance. Success elements for this position will be to establish clear and meaningful timeline expectations from internal and external teams while concurrently identifying associated risks for leadership to review. If you thrive in a Tech Ops environment and possess a unique blend of project management expertise, manufacturing technical understanding and logistical acumen, this position is for you.  

 

Primary Responsibilities:

• • Oversee technical bioprocess design and execution of upstream and downstream processes at CDMOs by tracking vendor performance and process metrics
  • Review current and past GMP and development data to synthesize actionable insights from process documentation and communicate this through technical reports or presentations to leadership
  • Review process data to identify areas for yield improvement or process characterization studies to support at-scale ranges
  • Collaborate with Tech Ops, Process Sciences, Quality, Regulatory and Clinical teams to assess and manage drug substance deviations, ensure adequate documentation to support disposition, and confirm that implemented CAPAs are effective 

• Ensure compliance with all relevant cGMP regulations

• Coordinate and facilitate document review across internal CMC functions & external CDMO partners to ensure compliance, accuracy, and change control
• Identify scopes of work at CDMOs that are needed to support program needs and be responsible from initiation through tracking and closure activities.
• Contribute to CMC budgeting and timeline development
• Leverage your past manufacturing and development experience as the process owner for aTyr for during at-scale manufacturing via Person-In-Plant responsibilities (PIP)
• Occasional long travel periods will be required up to 50%

 

Qualifications:

• • Bachelor’s degree in science or engineering
  • 4-6 years of relevant experience in a biotechnology or pharmaceutical company overseeing development or manufacturing at a CDMO
  • Demonstrated E. coli upstream or downstream biologics manufacturing expertise
  • Functional knowledge of GMPs with a proven track record of successful process design and execution
  • Preference for candidates with late-phase or commercial supply experience
  • Strong understanding of E. coli upstream or downstream development with scaling or transferring E. coli manufacturing processes 
  • Proficient in MS Excel, Smartsheet, Visio, ERP systems, and Power BI (or similar applications)
  • Excellent analytical, problem-solving, and communication skills

• APICS , CSCMP, or PMP certification is a plus

Further Recruiting Information

The salary range for this position is $130,000-$157,000 per year. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability, time-off, and 401(k)-matching contribution.

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.  aTyr Pharma, Inc. is committed to providing equal employment opportunities to all applicants and employees. We are committed to providing a workplace free of discrimination and harassment based on any protected characteristic. In accordance with the Americans with Disabilities Act (ADA) and other applicable laws, we will provide reasonable accommodations for qualified individuals with disabilities who are employees or applicants for employment, unless to do so would cause an undue hardship.

For consideration, please submit your resume and cover letter referencing job #222CS to jobs@atyrpharma.com.  aTyr Pharma, Inc. is an EEO employer.

About Us: 

aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. 

Overview:

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. 

Role Description: 

The Contracts Manager will be a key member of the legal team, responsible for the end-to-end management of a diverse portfolio of contracts from contract-request intake through execution and filing. This role requires a highly organized and detail-oriented individual with a strong understanding of legal principles and the ability to work independently and collaboratively in a fast-paced environment. Experience in the life sciences industry, particularly with a commercial focus, is highly desired. 

 

Primary Responsibilities:

• Draft, negotiate, and manage a wide range of contracts, including master services agreements, clinical trial agreements, consulting agreements, confidentiality agreements, work orders, and data privacy agreements.
• Collaborate closely with General Counsel, finance, clinical operations, and other internal stakeholders to ensure timely and efficient initiation, review, execution, and administration of contracts and agreements.
• Support negotiations of contracts to ensure appropriate business and legal terms, including triaging, reviewing, identifying issues for escalation and recommending contract language.
• Work closely with General Counsel to develop template agreements and acceptable fallback language.
• Collaborate with the clinical operations team to support the Company’s clinical trials, including managing the clinical trial start-up process and serving as the primary contact with clinical sites for contracts. 
• Partner closely with internal and external teams, including third-party vendors, to ensure timely turnaround and negotiation of agreements.
• Interact with various internal clients and functional groups to effectively address legal and business questions and provide guidance as well as practical solutions.
• Maintain and manage contracts workflow in an organized manner, including assisting with implementation of contract systems and processes.
• Manage the Company’s contract database and ensure accurate record-keeping.
• Assist in training and guiding business teams on contract processes and good contracting practices.
• Assist with and provide professional business advice related to implementing new contracts, policies and procedures.
• Work mostly independently, proactively initiating new projects and identifying ways to continuously improve contract processes and operations while exercising appropriate professional judgment.
• Other duties as assigned.

Qualifications:

• Bachelor’s degree in a relevant field (e.g. business, life sciences, paralegal) Paralegal certification preferred.
• At least 10 years of relevant experience as a contracts manager or paralegal, with a significant portion of that time spent in the life sciences industry, preferably with a commercial company. Extensive experience drafting, reviewing, managing, and assisting with negotiating a wide range of agreements, particularly clinical trial agreements.
• Proficient with MS Word, PowerPoint and Excel.
• Experience working with CROs and other clinical trial vendors. 
• Familiarity with industry standards and best practices in contract management.
• Excellent interpersonal, verbal, and written communication skills.
• Effective time management, initiative, follow-through, and organization skills.
• Detail-oriented with a commitment to accuracy.
• Exercises discretion and good judgment while handling confidential and sensitive information with the ability to show good judgment, honesty, and trust-building behaviors in all dealings.
• Able to collaborate, as well as to work independently while balancing competing priorities in a fast-paced, deadline-driven environment with a high level of professionalism.
• Self-motivated, with initiative and the ability to take ownership of, and follow through with, specific tasks.

Further Recruiting Information

The salary range for this position is $118,000-150,000 per year. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability, time-off, and 401(k)-matching contribution.

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.  aTyr Pharma, Inc. is committed to providing equal employment opportunities to all applicants and employees. We are committed to providing a workplace free of discrimination and harassment based on any protected characteristic. In accordance with the Americans with Disabilities Act (ADA) and other applicable laws, we will provide reasonable accommodations for qualified individuals with disabilities who are employees or applicants for employment, unless to do so would cause an undue hardship.

For consideration, please submit your resume and cover letter referencing job #220ND to jobs@atyrpharma.com.  aTyr Pharma, Inc. is an EEO employer.