| Program | Indication | Research | Preclinical | Phase 1 | Phase 2 | Phase 3 |
|---|---|---|---|---|---|---|
| Efzofitimod (ATYR1923) |
Pulmonary Sarcoidosis |
|
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| Other ILDs (CTD-ILD; CHP)(1) |
|
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| Healthy Japanese Volunteers(2) |
|
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| ATYR2810 | Solid Tumors |
|
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| NRP2 mAbs | Cancer; Inflammation |
|
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| AARS-1; DARS‑1(3) | Cancer; Fibrosis; Inflammation |
|
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| Program | Target | Phase |
|---|---|---|
| Efzofitimod (ATYR1923) | Pulmonary Sarcoidosis | Phase 2 |
| Other ILDs (CTD-ILD; CHP)1 | Phase 1 | |
| Healthy Japanese Volunteers2 | Phase 1 | |
| ATYR2810 | Solid Tumors | Preclinical |
| NRP2 mAbs | Cancer; Inflammation | Research |
| AARS-1; DARS-1(3) | Cancer; Fibrosis; Inflammation | Research |
(1) CTD-ILD: connective tissue disease-related ILD (e.g. Scleroderma-related ILD); CHP: chronic hypersensitivity pneumonitis
(2) In partnership with Kyorin Pharmaceutical Co., Ltd. Kyorin’s Phase 1 study in healthy Japanese volunteers has been completed. Kyorin is eligible to participate in future efzofitimod trials sponsored by aTyr.
(3) The next two candidates from our tRNA synthetase platform; initial focus on NK cell biology.