Career Opportunities

aTyr offers a competitive compensation package with stock options. We also offer a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) plan matching contribution. For consideration, please submit your resume and cover letter referencing one of our open position numbers to jobs@atyrpharma.com.

aTyr is an equal opportunity employer and makes employment decisions without regard to age, race, ancestry, color, sex, national origin, sexual orientation, gender, gender identity, gender expression, religious creed, disability, medical condition, genetic information, marital status, veteran status or participation in the uniformed military services of the United States, including the National Guard.

Open Positions:

Senior Research Associate, Protein Production

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. An excellent opportunity to become a central member of a supportive and tight-knit team is currently available at aTyr.

Position Summary

We are currently seeking a Senior Research Associate to join the Process Sciences team as we focus on the development of novel medicines derived from our research into new biological pathways. The successful candidate will play an important role in the discovery and development of new drug candidates through the generation of high quality proteins for research use and support of manufacturing process development for clinical candidates.   Primary laboratory responsibilities include upstream protein production with mammalian cell culture processes, DNA production and purification, some cloning work, and related inventory management. Dependent upon experience and interest, there are growth opportunities to work within other functional groups.

Qualifications

The role requires the ability to collaborate with colleagues in a cross-functional, fast-paced team environment. The successful candidate will be self-motivated, meticulous, organized, and flexible, with the ability to handle rapidly changing objectives and timelines. Experience in an industrial lab focused on protein therapeutics discovery/development is also desired.

The ideal candidate will have:

  • BS with 5+ years of biopharmaceutical industry experience or equivalent
  • Experience in development and execution of mammalian cell culture processes for protein production with proven aseptic technique
  • Experience in harvest, clarification, and recovery processes
  • Molecular biology experience with cloning and DNA production experience is a plus
  • Organized and able to plan and execute multiple activities in parallel using efficient time management
  • High level of motivation and initiative with ability to quickly identify issues, troubleshoot, and implement changes as needed
  • Work well independently as part of a dynamic team and collaborate with cross-functional groups
  • Excellent written and verbal communication skills

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

Associate Director, Clinical Operations

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

The Associate Director, Clinical Operations will oversee global clinical trials

This key role will manage, plan, and execute clinical trials, including creating and managing study timelines, budgets, and study management plans. Additionally, s/he will provide guidance and shared learning with and across teams throughout planning and implementation, as well as ensure clinical operational and development

deliverables and timelines are met. This position will report to the Head of Clinical Operations.

Primary Responsibilities:

    Manage and lead a team in clinical operations

    Manage and execute clinical programs, including study management, budget and timeline creation

    Lead across functional study teams, and understand the intricacies among the different groups

    Participate in the development of protocols, IBs, CSRs and other clinical documents, ensuring they are completed within study timelines

    Participate in preparation of regulatory filings (e.g. IND, pre-IND, orphan applications etc.) as needed

    Partner with CMC/clinical supplies to provide drug supply assumptions and contribute to design and packaging of supplies for clinical trials

    Manage all aspects of study progress from planning to close-out to assure adherence to intended timelines and achievement of study goals while ensuring quality in accordance with FDA, EMEA, GCP, and ICH guidelines

    Ability to build strong KOL and Principal Investigator relationships

    Liaise with clinical site staff and Investigators as appropriate to ensure optimal Sponsor-site relationships

    May attend and/or participate in Qualification, Initiation and Monitoring site visits

    Lead, plan, and execute clinical Investigator meetings, study meetings, and vendor meetings as needed

    Lead the evaluation, selection and management of Contract Research Organizations (CROs) and other external vendors to ensure successful clinical trial implementation and execution

    Author informed consent forms (ICFs), study management plans and other clinical documents as necessary.

    Provide study specific training as needed

    Develop and ensure execution of activities outlined in various study plans (data management, safety management, and study communication plans)

    Assist in authoring, reviewing and revising of SOPs

    Assist in training of new staff and consultants

    Attend clinical, scientific and industry conferences as needed 

Qualifications:

    Bachelor’s degree required.

    Minimum of 8+ years in clinical operations in the pharmaceutical/biotech industry (5+ years of study management)

    Experience managing clinical trials, budgets, and timelines

    Experience monitoring and/or overseeing clinical studies and conducting PSVs, SIVs, IMVs, and COVs

    Experience managing CROs (or similar), multiple vendors, and complex protocols

    Experience with protocol, ICF, and CSR development

    Experience in global clinical trial management

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job #181LC to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Clinical Trial Manager, Trial Operations Supply Management

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

The Clinical Trial Manager, Clinical Operations Supply is responsible for the management and oversight of clinical trial material supply chain activity, ancillary clinical supplies and laboratory management of central and specialty laboratories for aTyr Pharma Clinical Trials.

This key role is in the clinical operations group and works closely with stake holders including Clinical Operations, Quality Assurance, Regulatory Affairs, CMC, Research, Contract Manufacturing Operations (CMO’s), and Contract Research Organizations (CRO’s) to ensure seamless supply of Clinical Trial Material, ancillary study supplies and laboratory management.  Some key areas of management/oversight include forecasting, packaging, labeling, distribution of clinical trial material, as well as inventory management of ancillary supplies, vendor oversight of laboratories and CROs, and eTMF filing of Clinical CTM, ancillary supply and laboratory documents.  A successful candidate will be skilled at understanding the Clinical Supply and laboratory needs and responsibilities, exhibit strong attention to detail, support a collaborative environment, and strong ability to manage workload and meet project timelines.

Primary Responsibilities:

  • Clinical Trial Material
    • Manage packaging, labeling, and distribution of clinical trial material for global clinical trials.
    • Drive label creation and approval process, including translations and regulatory requirements
    • Support (Interactive Response Technology) IRT development, user acceptance testing (UAT), and system oversight, as well as utilize the system to actively manage clinical trial material.
    • Utilize and support the budget forecasting and planning
    • Partner with Clinical Operations Lead to align on demand assumptions
    • Develop supply strategies to maximize supply efficiency and minimize waste
    • Design and actively manage supply & demand forecasts
    • Identify potential supply risks, and develop risk mitigation plans as necessary
    • Communicate clinical supply requirements to CMC team and ensure seamless coordination of demand and supply
    • Function as the unblinded aTyr representative if required
      • Resource to unblinded site and CRO team
      • Oversight of drug accountability and monitoring, review of unblinded monitoring reports
      • Assist with study plans, training and SIVs as needed
    • Support return and destruction of clinical trial material for assigned protocols
  • Ancillary Clinical Trial Supplies
    • Identify and procure ancillary supplies as needed per protocol
      • Comparators
      • Freezers
      • ECGs, pulse oximeters, etc.
    • Laboratory
      • Oversight of central laboratories utilized in clinical trials
      • Assists Clinical Operations Study Lead in the identification, qualification and selection of laboratory vendors
      • Collaborate with Research and Clinical Science with regard to needs for additional analyses that may be required (PK, PD, ADA, etc).
      • Sample management and long term sample storage oversight
    • General
      • Assist in SOP review and development
      • Assist in other areas of clinical operations as needed.

    Qualifications:

    • Bachelor’s degree
    • Experience: 5+ years of relevant experience
    • Experience with vendor oversight and global trials
    • Understanding of clinical supply chain activity
    • Experience with IRT systems
    • Strong understanding of FDA, EMEA, GCP and ICH guidelines
    • Ability to utilize MS Office (Excel, PowerPoint, Visio, Project, etc)
    • Demonstrated flexibility to adapt to external environment influences through identifying new strategies and tactics
    • Strong attention to detail
    • Excellent communication, collaboration, and influencing skills
    • Ability to multi-task and manage complex challenges
    • Ability and willingness to travel as needed positive management approach
    • Maximum flexibility to adapt to changing program needs in real time
    • Excellent oral, written, and communication skills required
    • Ability and willingness to travel as needed

    Further Recruiting Information

    For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

    In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

    For consideration, please submit your resume and cover letter referencing job #181LC to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Associate Director/Director Process Sciences

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage recombinant Fc fusion expressed in E. coli which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Position Summary

This position within the Process Sciences group is for an Associate Director/Director to lead technology transfer, development and manufacturing activities at contract manufacturing organizations, and participate in strategic CMC planning and messaging to program teams and Executive Leadership. The candidate will collaborate with Quality, Regulatory, Clinical, and Research functional areas to help advance clinical and pre-clinical programs. The role also requires working closely with Analytical / Formulation, Upstream and Downstream team members and provide technical guidance for internal lab-scale research protein production and development operations.

The specific responsibilities include:

  • Manage technical development and manufacturing operations at Contract Development and Manufacturing Organization (CDMOs)
  • Ensure timely cGMP manufacture with adherence to Quality Management Systems
  • Develop/direct robust, scalable, well characterized and cost-effective processes for the biologics pipeline
  • Manage process scale-up, facility fit analysis, optimization studies and process transfer
  • Manage late-stage clinical CMC development including process characterization/validation studies (e.g. scale-down models and design of experiment approach to identify critical process parameters) and process validation at the CDMO, including review of development, process characterization and validation protocols and reports
  • Serve as subject matter expert and provide technical expertise for process-related trouble-shooting, and Quality support leveraging industry-standard root cause analysis methodologies.
  • Communicate clearly with program stakeholders, technical staff, consultants and CDMO partners
  • Write and review high quality source documentation to support global regulatory filings

Requirements

  • A Master’s or Ph.D. degree (Ph.D. preferred) in Biochemistry, Chemical/Biochemical Engineering, Chemistry, Biological Sciences or other relevant science or engineering field, with at least 10+ years of relevant industrial experience
  • Strong background and subject matter expertise in upstream or downstream unit operations including cell line development, bioreactor operations, clarification, liquid chromatography, ultrafiltration/diafiltration, viral clearance and the impact of process conditions on product quality and scale-up manufacturing of recombinant proteins and antibodies
  • Demonstrated process development, technology transfer and scale-up of bioprocess manufacturing experience
  • Demonstrated process characterization and validation experience
  • Working familiarity with analytical method requirements stage-appropriate to program development status
  • Extremely detail-oriented, thorough, and diligent in experimental design, data analysis and review
  • Experience with both mammalian and microbial systems is highly desirable
  • Knowledge of cGMP and regulatory requirements related to biologics manufacturing and controls, including authoring relevant CMC sections of IND/BLA filings
  • High level of motivation, initiative and creativity
  • Excellent organizational skills and ability to execute on multiple projects in parallel
  • Excellent written, verbal and presentation communication skills
  • Comfortable working in a high impact, fast-paced and lean biotech start-up environment
  • Ability to learn and act on dynamic information at a rapid pace

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

Senior Research Associate, In Vitro Biology

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Primary Responsibilities:

We are seeking a Senior Research Associate with experience in ELISA-based assay development and sample testing to join our In Vitro Biology team working on the development of novel therapeutics for serious diseases.

The ideal candidate will be experienced in ELISA based techniques, including the development of assays and testing of clinical and pre-clinical samples. Experience with cell culture and a variety of cell-based assays would be helpful. The candidate should be comfortable working with human serum samples and primary cells. Experience in standard biochemical techniques is required. Must be able to accurately communicate, document and present your findings from a wide range of experimental studies. This candidate will work with experienced scientists at aTyr to discover and develop novel immunomodulatory molecules, and make an important contribution to our research team.

Qualifications:

  • Bachelor’s degree in biology or a related subject with 5+ years of research experience in a hands-on laboratory role

  • Well versed in biochemical and immunological techniques including ELISA

  • Experience or willingness to work with human serum/plasma samples

  • Familiar in cell culture & cell-based assays

  • The ability and enthusiasm to learn new techniques and apply them carefully to solve biological problems

  • Capable of designing experiments, generating data and interpreting results in collaboration with a highly motivated team

  • An excellent communicator, well-organized and able to work effectively in a team environment to assist the success of the team

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job 176RA to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

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