Research Associate/ Sr. Research Associate, Immunology

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Primary Responsibilities:

We are seeking an experienced, creative and motivated Research Associate/Senior Research Associate to join our Immunology Team. In this role, you will contribute to the company’s efforts to develop and characterize novel therapeutic candidates for cancer and inflammatory diseases.

The successful candidate will have a strong immunology background and will be expected to work in an engaged manner in a collaborative cross-functional team environment, perform experiments, organize and analyze results, communicate effectively and present findings in team meetings.

Responsibilities include, but are not limited to:

  • In vitro and ex vivo cell culture and phenotyping of immune cells including, but not limited to T cells and myeloid cells
  • Perform functional assays to evaluate the efficacy and characterize mechanism of action of our therapeutic candidates in immune cells
  • Independently plan and execute in vitro functional assays with human and murine cells according to project timelines and goals
  • Maintain up-to-date knowledge of immunology/immunotherapy field
  • Coordinate tasks across projects, demonstrating prioritization and planning
  • Effectively communicate plans and results in both oral and written form
  • Ability to work in a highly dynamic collaborative team environment

Qualifications:

  • Undergraduate or master’s degree in Immunology/Cell Biology
  • Excellent mammalian cell/tissue culture and sterile technique required
  • Hands-on experience in immunology and/or oncology, preferably with isolation, manipulation and functional analysis of human immune cells subsets in whole blood and PBMC
  • Expertise with primary myeloid cell-based assays required
  • Extensive experience culturing primary immune cells required
  • Expertise with multi-color flow cytometry (6+ colors) and data analysis (FACSDiva, FlowJo) highly desirable, but not required
  • Knowledge of cytokine biology desirable
  • Self-motivated and willing to accept temporary responsibilities outside of initial job description
  • Strong organizational skills and record keeping
  • Proficient in using data management programs such as MS Office and Graph Pad Prism Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job #203SP to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Senior Scientist, Immunology

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Primary Responsibilities:

aTyr Pharma is seeking an outstanding individual to join our Immunology Team. The Senior Scientist will play an integral part in the development and characterization of novel immunomodulatory therapeutic candidates for the treatment of cancer and other inflammatory diseases. The ideal candidate will be a highly motivated independent individual who leads from the bench and enjoys having broad responsibilities and opportunities.

  • Design and execute MOA studies using methods such as multi-color flow cytometry, gene expression analysis techniques, MSD and other immunological assays
  • Independently troubleshoot technical issues and develop optimized processes and assays for critical tasks
  • Work together with other departments within the company as well as with external collaborators
  • Be an active participant in internal and external meetings
  • Supervise/mentor research associate(s)
  • Contribute to a dynamic, exciting culture that embraces team work and innovation

Qualifications:

The role requires the ability to collaborate with colleagues in a cross-functional, fast-paced team environment. The successful candidate will be self-motivated, resourceful, and flexible with the ability to handle rapidly changing objectives and timelines. The ideal candidate will have:

  • PhD with postdoc experience in immunology (5-7 years’ industry experience)
  • Background in immunology is required, with background in oncology and or fibrosis a plus
  • Ability to independently design, plan, execute and interpret experiments
  • Hands-on experience and troubleshooting proficiency with immune cell isolation from peripheral blood and leukopak, cell expansion, and cell based immunoassays
  • Demonstrated experience with immunological assays to assess and characterize cell function such as cytokine secretion, differentiation, activation, cytotoxicity, proliferation and suppression assay
  • Broad expertise in cellular immunology, tumor immunology, molecular biology, and flow cytometry
  • Expertise with multi-color flow cytometry (immune cell profiling, at least 8 colors) and flow data analysis is required, cell sorting experience a plus
  • Proven track record of success through publications and presentations
  • Excellent organizational and planning skills
  • Excellent interpersonal, oral and written communication skills are essential in this collaborative environment

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job #194SP to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Director, Clinical Science

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. In close collaboration with the study medical monitor, provide scientific guidance and support to the team. The Director, Clinical Science will be responsible for various aspects of clinical study execution including: protocol writing, building study infrastructure, staff training, data cleaning/analysis, investigator interaction and support of regulatory filings.

Primary Responsibilities:

  • Leads the development and execution of clinical strategies and study plans, applying strong scientific knowledge and operational knowledge that translate research plans into high quality studies.
  • Maintains strong scientific and clinical knowledge in specific therapeutic and relevant disease indications to assist in study concept and protocol development.
  • Provides scientific and medical expertise to collaborate with other departments on final study design, protocol, and informed consent design.
  • Writes medical data review plans, charters and specific sections of study manuals and investigator meeting materials.
  • Contributes to the development of CRFs, data checks, patient profiles and statistical analysis plans.
  • Leads internal clinical data review meetings in collaboration with the clinical lead/medical monitor; supports ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
  • Organizes and manages external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, as directed by the medical monitor.
  • Provides analytical support of clinical trial data (safety, efficacy and biomarkers), including gathering, analyzing, reviewing, interpreting, and providing preliminary assessments and recommendations.
  • Develops or contributes to abstracts, manuscripts, clinical presentation slides and other external facing materials.
  • Addresses investigator questions regarding protocol and related scientific issues.
  • Assists in writing or reviewing regulatory documents such as briefing books or health authority requests for information, IND annual reports, Investigator Brochures, and regulatory filings.
  • Identify risks and recommends potential mitigation strategies that can impact the successful execution of a clinical study
  • Assists in close out of clinical studies by writing clinical science sections and assisting in the development and review of other clinical documentation required for regulatory submissions and other regulatory processes
  • Supports and mentors Clinical Science/Medical staff
  • This position will work closely with Clinical Operations, Regulatory, Biostatistics, Data Management & Non-Clinical Research teams.

Qualifications:

Minimum Education/Experience

  • PharmD, PhD, MSN, MD preferred; other life sciences degrees considered if accompanied by extensive scientific and/or drug development experience
  • 8+ years of relevant industry experience working for biotechnology or pharmaceutical company in clinical development with knowledge of drug development process.
  • Respiratory, immunology and/or oncology experience in the clinical science role strongly preferred.
  • Proven experience in the submission of INDs and BLAs, as well as interactions with US and EU health authorities.
  • Proven success in conducting global Phase 1 through 3 clinical studies
  • Flexible and adaptable to quickly changing priorities, and willingness to move between projects to provide support/expertise as business needs dictate.
  • Experienced with data capture and analysis programs such as Prism, JMP, SpotFire and Medidata Rave or similar.
  • Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards.

Other Qualifications

  • Excellent oral and written communication skills; able to explain complex issues in a simple manner.
  • Ability to work effectively in a fluid, fast-paced team-based environment
  • Self-motivated, self-disciplined and able to function independently as well as part of a team
  • Highly organized with attention to detail, clarity, accuracy and conciseness
  • Excellent computer proficiency (G-Suite, MS Office Suite)

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job #196GW to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Financial Reporting Analyst

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever.

Primary Responsibilities:

  • Manage updates to the Company’s SOX compliance documentation including Control Matrices, Process Narratives, and monitoring compliance through interviews and document review
  • Coordinate with external SOX service provider walkthroughs, testing and process reviews
  • Assist with flowcharting SOX processes
  • Provide SOX training to process owners in their preparation of controls documentation and testing of SOX controls
  • Recommend best practices to the process owners regarding remediation of findings
  • Develop strong relationships with internal business partners and act as a subject matter expert in the design and implementation of controls
  • Review test findings and facilitate remediation of control gaps and escalate possible critical issues to the senior management of the company
  • Assist in preparation of SEC filings, including but not limited to: 10-Q, 10-K, proxy statement, 8-K and Section 16 filings
  • Generate monthly financial statement reports
  • Assist in preparation of the budget templates and roll-up’s
  • Assist accounting for all equity plan activity, including stock-based compensation expense
  • Participate in ad-hoc projects

Qualifications:

  • Must be a CPA or CPA candidate
  • Possess 2-3 years of experience with a public Biotech company
  • Experience with budget and forecast templates
  • Possess technical expertise related to Sarbanes-Oxley requirements, COSO Framework, Internal Audit and Internal Controls
  • Recent experience with SOX controls documentation and testing
  • Experience in end-to-end project management, controls evaluation, and cross-functional collaboration
  • Strong organizational, analytical, and problem-solving skills
  • Ability to multi-task and prioritize to meet deadlines
  • Excellent communication skills, both written and verbal
  • Self-motivated, proactive and detail oriented
  • Proficient with Microsoft Office applications

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

For consideration, please submit your resume and cover letter referencing job #188AP to jobs@atyrpharma.com. aTyr Pharma, Inc. is an EEO employer.

Senior Research Associate, Protein Production

About Us

aTyr Pharma is a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is ATYR1923, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to down-regulate immune engagement in inflammatory lung diseases. aTyr is publicly traded on Nasdaq under the symbol “LIFE”. For more information, please visit http://www.atyrpharma.com.

Overview

Patients and their challenges provide tremendous drive and meaning to what we do at aTyr. We seek a talented and successful individual that deeply desires to participate in our process to make medicines that change a patient’s life forever. An excellent opportunity to become a central member of a supportive and tight-knit team is currently available at aTyr.

Position Summary

We are currently seeking a Senior Research Associate to join the Process Sciences team as we focus on the development of novel medicines derived from our research into new biological pathways. The successful candidate will play an important role in the discovery and development of new drug candidates through the generation of high quality proteins for research use and support of manufacturing process development for clinical candidates. Primary laboratory responsibilities include upstream protein production with mammalian cell culture processes, DNA production and purification, and related inventory management. Dependent upon experience and interest, there are growth opportunities to work within other functional groups.

Qualifications

The role requires the ability to collaborate with colleagues in a
cross-functional, fast-paced team environment. The successful candidate will be self-motivated, organized, and flexible, with the ability to handle rapidly changing objectives and timelines. Preference given to candidates with industry experience.

The ideal candidate will have:

  • BS with 5+ years of experience in mammalian cell culture processes for protein production
  • Experience in harvest, clarification, and recovery processes
  • DNA production experience is a plus
  • Organized and able to plan and execute multiple activities in parallel using efficient time management
  • High level of motivation and initiative with ability to quickly identify issues, troubleshoot, and implement changes as needed
  • Work well independently as part of a dynamic team and collaborate with cross-functional groups
  • Excellent written and verbal communication skills

Further Recruiting Information

For additional information about aTyr Pharma, please visit our website at www.atyrpharma.com.

In addition to a competitive compensation package with stock options and an Employee Stock Purchase Plan, aTyr Pharma also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, life, disability and a 401(k) matching contribution.

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