Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Adams RA, Fernandes-Cerqueira C, Notarnicola A, Mertsching E, Xu Z, Lo WS, Ogilvie K, Chiang KP, Ampudia J, Rosengren S, Cubitt A, King DJ, Mendlein JD, Yang XL, Nangle LA, Lundberg IE, Jakobsson PJ, Schimmel P.
Cell Mol Immunol. 2019 Dec 4.
ATYR1923 Modulates the Inflammatory Response in Experimental Models of Interstitial Lung Disease
American Thoracic Society, 2019
The N-terminal domain of HARS is a novel NRP2 ligand and can regulate NRP2-dependent macrophage function
American Association for Cancer Research, 2019
ATYR1923 Reduces Neutrophil Infiltration in an Acute Lipopolysaccharide (LPS) Lung Injury Model
Keystone Symposia, 2019
ATYR1923 Ameliorates Dermal and Pulmonary Fibrosis in a Murine Model of Sclerodermatous Chronic Graft vs. Host Disease
Scleroderma Foundation National Patient Education Conference, 2018
Preclinical Characterization of ATYR1923 (iMod.Fc), an Immune-Modulatory Therapeutic With Potentially Broad Application in Interstitial Lung Diseases
American Thoracic Society, 2018
Identification of a T Cell Immunomodulatory Domain in Histidyl-tRNA Synthetase
American Association of Immunologists, 2018
Resokine Modulates Immune Cell Infiltration Into the Lung and Provides Therapeutic Activity in a Bleomycin-induced Lung Fibrosis Model
American Thoracic Society, 2017
Bi-allelic Mutations in the Phe-tRNA Synthetase Associated with Multi-system Pulmonary Disease Supports Non-Translation Function.
Xu Z, Lo WS, Beck D, Schuch L, Ola´hova´ M, Kopajtich R, Chong Y, Alston C, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc C, Borczuk A, Teich A, Juusola J, Sofeso C, Muller C, Pierre G, Hilliard T, Turnpenny P, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle L, Yang XL, Zhang M, Taylor R, Prokisch H, Griese M, Chung W, Schimmel P. The American Journal of Human Genetics July 2018 (103): 100–114.
The Resokine Pathway is Implicated in the Pathology of Interstitial Lung Disease
American Thoracic Society, 2017